The effect of fasting on Inflammation

Traba, J, Kwarteng-Siaw, M, et al. Fasting and Refeeding Differentially Regulate Nlrp3 Inflammasome Activation in Human Subjects. J Clin Invest 125(12)4592-600. PMC4665779


This study showed that on the cellular level, fasting has an anti-inflammatory effect with a positive impact on health outcomes.  The researchers concluded that their data indicate that nutrient levels regulate the NLRP3 inflammasome, in part through SIRT3-mediated mitochondrial homeostatic control.  These results suggest that deacetylase-dependent inflammasome attenuation may be amenable to targeting in human disease.


Rheumathoid arthritis

Kjeldsen-Kragh, J, Mellbye, OJ, et al. Changes in Laboratory Variables in Rheumatoid Arthritis Patients During a Trial of Fasting and One-Year Vegetarian Diet. Scand J Rheumatol 24(2)85-93.

It was previously reported that significant improvement might be obtained in rheumatoid arthritis patients by fasting followed by a vegetarian diet for one year.  The present study examined the changes in biochemical and immunological variables brought about by fasting and a vegetarian diet compared to a control group of omnivores.  It supported previous findings that diet could be useful in the treatment of rheumatoid arthritis.