Traba, J, Kwarteng-Siaw, M, et al. Fasting and Refeeding Differentially Regulate Nlrp3 Inflammasome Activation in Human Subjects. J Clin Invest 125(12)4592-600. PMC4665779
This study showed that on the cellular level, fasting has an anti-inflammatory effect with a positive impact on health outcomes. The researchers concluded that their data indicate that nutrient levels regulate the NLRP3 inflammasome, in part through SIRT3-mediated mitochondrial homeostatic control. These results suggest that deacetylase-dependent inflammasome attenuation may be amenable to targeting in human disease.
Kjeldsen-Kragh, J, Mellbye, OJ, et al. Changes in Laboratory Variables in Rheumatoid Arthritis Patients During a Trial of Fasting and One-Year Vegetarian Diet. Scand J Rheumatol 24(2)85-93.
It was previously reported that significant improvement might be obtained in rheumatoid arthritis patients by fasting followed by a vegetarian diet for one year. The present study examined the changes in biochemical and immunological variables brought about by fasting and a vegetarian diet compared to a control group of omnivores. It supported previous findings that diet could be useful in the treatment of rheumatoid arthritis.