Ketogenesis and Obesity Related Disease

Tendler, D, Lin, S, et al. The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease: A Pilot Study. Dig Dis Sci 52(2)589-93.

This was a pilot study done on 5 patients suffering from nonalcoholic fatty liver disease, a disease becoming increasing common as obesity rates rise.   It proved that six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease.

 

Haimoto, H, Iwata, M, et al. Long-Term Effects of a Diet Loosely Restricting Carbohydrates on Hba1c Levels, Bmi and Tapering of Sulfonylureas in Type 2 Diabetes: A 2-Year Follow-up Study. Diabetes Res Clin Pract 79(2)350-6.

In this study two groups of type II diabetic patients were followed for two years.   One of the groups followed a conventional diet while the other group followed a carbohydrate restricted diet.   After the two years, HbA1c, BMI and cholesterol levels were significantly improved in the last group, while less medication was needed.