Ketogenesis and Neuro Protection

Arslan, N, Kose, E, et al. The Effect of Ketogenic Diet on Serum Selenium Levels in Patients with Intractable Epilepsy. Biol Trace Elem Res 178(1)1-6.

This study showed that continous following of high fat, low carb diet has a consequent drop in serum selimium levels.  Therefore it is advised that selinium is supplemented in the long term when following the diet.  this study was specifically daone on children suffering from epilepsy.


Choragiewicz, T, Zarnowska, I, et al. [Anticonvulsant and Neuroprotective Effects of the Ketogenic Diet]. Przegl Lek 67(3)205-12.

This study  suggest that the ketogenic diet also has neuroprotective properties, which makes it a useful alternative therapeutic method in the modification of the natural history of the diseases related with neurodegeneration processes. 


Gumus, H, Bayram, AK, et al. The Effects of Ketogenic Diet on Seizures, Cognitive Functions, and Other Neurological Disorders in Classical Phenotype of Glucose Transporter 1 Deficiency Syndrome. Neuropediatrics 46(5)313-20.

 This study showed that treatment with KD resulted in a marked improvement in seizures and cognitive functions of children suffering from epilepsy as a result of  glucose transporter protein 1 deficiency syndrome.  There were also improvement, although less striking on the other neurological disorders of the patients such as alertness, concentration, motivation and activity .


Kim, JA, Yoon, JR, et al. Efficacy of the Classic Ketogenic and the Modified Atkins Diets in Refractory Childhood Epilepsy. Epilepsia 57(1)51-8.

This study showed that a modified high protein diet had advantages with respect to better tolerability and fewer serious side effects.  this diet might be considered as the primary choice for the treatment of intractable epilepsy in children, but the classic ketogenic diet is more suitable as the first line of diet therapy in patients <2 years of age.


Sariego-Jamardo, A, Garcia-Cazorla, A, et al. Efficacy of the Ketogenic Diet for the Treatment of Refractory Childhood Epilepsy: Cerebrospinal Fluid Neurotransmitters and Amino Acid Levels. Pediatr Neurol 53(5)422-6.

This study showed a 50% reduction in rate of epileptic seizures in children suffering from it.  Although another goal of the study was to determine the mechanism of protection from the ketogenic diet, it did not succeed in this. 


Herbert, MR and Buckley, JA. Autism and Dietary Therapy: Case Report and Review of the Literature. J Child Neurol 28(8)975-82.

This as a case study of a child with autism and epilepsy who, after limited response to other interventions following her regression into autism, was placed on a gluten-free, casein-free diet.  Over the course of several years following her initial diagnosis, the child's Childhood Autism Rating Scale score decreased from 49 to 17, representing a change from severe autism to nonautistic, and her intelligence quotient increased 70 points.  Also, 14 months after the initiation of the diet the child was essentially seizure free.  Secondary benefits included resolution of morbid obesity and improvement of cognitive and behavioral features.


Husain, AM, Yancy, WS, Jr., et al. Diet Therapy for Narcolepsy. Neurology 62(12)2300-2.

This study showed that patients with narcolepsy experienced modest improvements in daytime sleepiness on a ketogenic diet.