Carotenoids and Cancer

Bladder Cancer

Ros, M, Bueno-de-Mesquita, B, et al. Plasma Carotenoids and Vitamin C Concentrations and Risk of Urothelial Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2012 Oct ;96(4):902-10. Epub 2012 Sep 5. PMID: 96(4)902-10. PMID: 22952186


This study showed that higher plasma carotenoids and vitamin C reduced therisk and severity of urothelial cell carcinoma (UCC) in humans.  856 patients with new;y diagnosed UCC participated this case-control study nested within the European Prospective Investigation into Cancer and Nutrition.


Pancreatic Cancer

Chen, J, Jiang, W, et al. Association between Intake of Antioxidants and Pancreatic Cancer Risk: A Meta-Analysis. Int J Food Sci Nutr.  30(1-13. PMID: 27356952


This was a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and a total of 18 studies were included. Comparing the highest with lowest categories, intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were associated with development of pancreatic cancer risk.  In conclusion, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.


Endometrial Cancer

Pelucchi, C, Dal Maso, L, et al. Dietary Intake of Carotenoids and Retinol and Endometrial Cancer Risk in an Italian Case-Control Study. Cancer Causes Control 19(10)1209-15.

This study provides information on the relation between intake of carotenoids and retinol and endometrial cancer.  454 women with endometrial cancer and 908 controls were studied.  The results supported previous reports that these nutrients could lower the risk of endometrial cancer in women.



Polesel, J, Talamini, R, et al. Nutrients Intake and the Risk of Hepatocellular Carcinoma in Italy. Eur J Cancer 43(16)2381-7.

A hospital-based case-control study was conducted in Italy in 1999-2002, including 185 patients with liver cancer and 412 cancer-free controls.  It looked at the effect of dietary consumption of linoleic acid and beta carotene on the risk of developing liver cancer. It found an inverse correlation between these variables, suggesting the consuption of foods rich in these nutrients protected against the disease.


Cancer of the mouth

Garewal, HS, Katz, RV, et al. Beta-Carotene Produces Sustained Remissions in Patients with Oral Leukoplakia: Results of a Multicenter Prospective Trial. Arch Otolaryngol Head Neck Surg 125(12)1305-10.

This study was done to confirm reports that beta-carotene produces regressions in patients with oral leukoplakia, a premalignant condition of the mouth.  Fifty four patients were studied for six months.  It was found that beta carotene helped to improve this condition, preventing it to develop in cancer.