Soy Aids Bone Health

Bitto, A, Burnett, BP, et al. Effects of Genistein Aglycone in Osteoporotic, Ovariectomized Rats: A Comparison with Alendronate, Raloxifene and Oestradiol. Br J Pharmacol 155(6)896-905. PMC2515927

This was a study done on mice.  It was found that consumption of soy could aid in the prevention of postmenopausal osteoporosis.  This study showed increased bone mass density as well as bone mineral density.

Anti-cancer Effects of Legumes

Faris, MA, Takruri, HR, et al. Chemopreventive Effect of Raw and Cooked Lentils (Lens Culinaris L) and Soybeans (Glycine Max) against Azoxymethane-Induced Aberrant Crypt Foci. Nutr Res 29(5)355-62.

This study was done on rats and showed the potential of lentil consumption as a protective agent against colon carcinogenesis.   It also indicated that lentils could slow down the development of the disease.

 

Tajaddini, A, Pourzand, A, et al. Dietary Resistant Starch Contained Foods and Breast Cancer Risk: A Case-Control Study in Northwest of Iran. Asian Pac J Cancer Prev 16(10)4185-92.

This was a study done on 306 women with breast cancer and 309 healthy controls.  The results show that certain foods, in particular whole wheat bread, legumes and boiled potato may reduce breast cancer risk, whereas higher intake of white bread and biscuits may be related to increased BC risk.

The Nightshades

Lablokov, V, Sydora, BC, et al. Naturally Occurring Glycoalkaloids in Potatoes Aggravate Intestinal Inflammation in Two Mouse Models of Inflammatory Bowel Disease. Dig Dis Sci 55(11)3078-85.

This was a study done on mice.  It demonstrated that consumption of potato skins containing glycoalkaloids can significantly aggravate intestinal inflammation in predisposed individuals.

 

 

Childers, N and Margoles, M. An Apparent Relation of Nightshades (Solanaceae) to Arthritis. Journal of Neurological and Orthopedic Medical Surgery 12(227-31.

This study describes the relationship between the consumption of nightshades and the development of arthritis.  Blackpepper is exempted frm this list.

 

 

Tingey, W. Glycoalkaloids as Pest Resistance Factors. American Potato Journal 61(157)

This study showed the potato glycoalkaloids have antimicrobal and pesticidal properties to protect them from their natural enemies.

 

 

Patel, B, Schutte, R, et al. Potato Glycoalkaloids Adversely Affect Intestinal Permeability and Aggravate Inflammatory Bowel Disease. Inflamm Bowel Dis 8(5)340-6.

This study found that concentrations of glycoalkaloids normally available while eating potatoes can adversely affect the mammalian intestine and can aggravate inflammatory bowel disease

 

 

Nisha, P, Abdul Nazar, P, et al. A Comparative Study on Antioxidant Activities of Different Varieties of Solanum Melongena. Food Chem Toxicol 47(10)2640-4.

This study showed that extracts from purple colour small size eggplant fruit demonstrated better antioxidant activities than the other bigger samples.  This my be attributed to the higher phenolic and anthocyanin content.

 

 

 

Mushrooms and Cognitive Function

Ray, B, Chauhan, NB, et al. The"Aged Garlic Extract:"(Age) and One of Its Active Ingredients S-Allyl-L-Cysteine (Sac) as Potential Preventive and Therapeutic Agents for Alzheimer's Disease (Ad). Curr Med Chem. 18(22)3306 -13. PMID: 21728972

 

This random controlled trial showed improved cognitive function in 30 Japanese men and women between the age of 50 and 80 years.  All of these participants had mild cognitive impairment.  This improvement was shown after 16 weeks of consumption of dry powder of the Yamabushitake mushroom

Anti-cancer effect of Alliums

Munday, R and Munday, CM. Relative Activities of Organosulfur Compounds Derived from Onions and Garlic in Increasing Tissue Activities of Quinone Reductase and Glutathione Transferase in Rat Tissues. Nutr Cancer 40(2)205-10.

This study confirmed suggestions from previous research that the organosulfur compounds of garlic and onions could help in the prevention and cure of cancer.  It is done by speeding up the second phase of the liver detox system.  This is a mechanism which could speed up detoxification as a whole, eliminating toxic waste in the body.

 

Cipolla, BG, Mandron, E, et al. Effect of Sulforaphane in Men with Biochemical Recurrence after Radical Prostatectomy. Cancer Prev Res (Phila) 8(8)712-9.

This was a double-blinded, randomized, placebo-controlled, multicenter trial including 78 prostate patients.  It showed that the daily administration of free sulforaphane shows promise in the management of prostate cancer after radical prostatectomy.  It might also help to reduce the risk of recurrence of the cancer.

 

Okano, J, Fujise, Y, et al. Chemoprevention against Hepatocellular Carcinoma. Clin J Gastroenterol. 4(4)185-97. PMID: 26189518

In this review article, sulpforaphane is listed as one of the natural substaces wich has protective activity against liver cancer.  This is valuable as many chronic liver conditions such as hepatitis may result in liver cancer if no protective measures are taken.

Cholesterol and Lipid Lowering Effect of Garlic and Mushroom

Mathew, B, Prasad, N, et al. Cholesterol-Lowering Effect of Organosulphur Compounds from Garlic: A Possible Mechanism of Action. Kathmandu Univ Med J 2(2)100-2. PMID: 15821374

 

This article tried to explain the mechanism by which organosulfur compounds lowers blood lipids.  It appears that the anti-cancer mechanism could be responsible for this action, blocking lipogenic pathways.  This make garlic useful as a protective mechanism in two major modern diseases namely cancer and hyper cholesterolemia.

 

Khatun, K, Mahtab, H, et al. Oyster Mushroom Reduced Blood Glucose and Cholesterol in Diabetic Subjects. Mymensingh Med J 16(1)94-9.

 

This study was undertaken to assess the effect of Oyster Mushrooms in reducing blood glucose, cholesterol and triglycerides (TG) in diabetic patients while testing for toxicity.  Thirty patients who all complied with a 24 day protocol were included in the study. It was found that the consumption of mushrooms lowered blood lipids, total cholesterol and TG significantly.

Garlic and Mushrooms Increases Immunity

Guo, NL, Lu, DP, et al. Demonstration of the Anti-Viral Activity of Garlic Extract against Human Cytomegalovirus in Vitro. Chin Med J (Engl) 106(2)93-6.

 

This study was done in a petri dish on human tissue infected by a virus, in this case the human cytomegalovirus .  It was found that the addition of garlic extract to the culture had an inhibitory effect on the virus which remained even after removal of the extract.  It was also found that continuous addition of the extract had a more powerful effect

 

 

Wesa, KM, Cunningham-Rundles, S, et al. Maitake Mushroom Extract in Myelodysplastic Syndromes (Mds): A Phase II Study. Cancer Immunol Immunother 64(2)237-47. PMC4317517

 

This study done on 21 patients showed mechanisms by which the consumption of maitake mushroom extract increased immunity.  It increased neutrofil and monocyte production as well as production of reactive oxygen species.  All of these target pathogens and consequently increase immunity.

Carotenoids and Eye Health

Macular degeneration

Parisi, V, Tedeschi, M, et al. Carotenoids and Antioxidants in Age-Related Maculopathy Italian Study: Multifocal Electroretinogram Modifications after 1 Year. Ophthalmology 115(2)324-33 e2.

This was a randomized control trial where 27 patients with age - related macular degeneration were enrolled.  They were tested for the effect of supplementation with vit C, vit E and carotenoids on the progression of the disease.  It was found that these nutrients did not only stop the progression, but even improved the condition of the retina, particularly the central area.

 

Cataracts

Christen, WG, Liu, S, et al. Dietary Carotenoids, Vitamins C and E, and Risk of Cataract in Women: A Prospective Study. Arch Ophthalmol 126(1)102-9. PMC2396535

 These prospective observational data examined the relation between dietary intake of carotenoids and vitamins C and E and the risk of cataract in 35 551 profesional women.  It was concluded that higher dietary intakes of these nutrients from food and supplements were associated with significantly decreased risks of cataract.

Carotenoids and bone health

Wu, A, Huang, C, et al. The Relationship between Vitamin a and Risk of Fracture: Meta-Analysis of Prospective Studies. J Bone Miner Res. 29(9)2032-9.

This was a meta analysis done on studies published in Medline and Embase to determine the relationship between vitamin A intake and the risk of hip fractures.  It was found that both high and low blood levels of retinol and vitamin A proposed a risk for fracturing a hip.  Because certain vegetables provide the body with carotenoids which develop into retinol and vitamin A as the body needs it, the authors of the study suggest that consumption of vegetables rich in caretonoids (specifically alpha and Beta carotene).  These nutrients, which should be converted to retinol in blood, may be better than intake of retinol from meat, which is directly absorbed into blood after intake, resulting in too high levels.

Carotenoids and Cancer

Bladder Cancer

Ros, M, Bueno-de-Mesquita, B, et al. Plasma Carotenoids and Vitamin C Concentrations and Risk of Urothelial Cell Carcinoma in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 2012 Oct ;96(4):902-10. Epub 2012 Sep 5. PMID: 96(4)902-10. PMID: 22952186

 

This study showed that higher plasma carotenoids and vitamin C reduced therisk and severity of urothelial cell carcinoma (UCC) in humans.  856 patients with new;y diagnosed UCC participated this case-control study nested within the European Prospective Investigation into Cancer and Nutrition.

 

Pancreatic Cancer

Chen, J, Jiang, W, et al. Association between Intake of Antioxidants and Pancreatic Cancer Risk: A Meta-Analysis. Int J Food Sci Nutr.  30(1-13. PMID: 27356952

 

This was a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and a total of 18 studies were included. Comparing the highest with lowest categories, intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were associated with development of pancreatic cancer risk.  In conclusion, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.

 

Endometrial Cancer

Pelucchi, C, Dal Maso, L, et al. Dietary Intake of Carotenoids and Retinol and Endometrial Cancer Risk in an Italian Case-Control Study. Cancer Causes Control 19(10)1209-15.

This study provides information on the relation between intake of carotenoids and retinol and endometrial cancer.  454 women with endometrial cancer and 908 controls were studied.  The results supported previous reports that these nutrients could lower the risk of endometrial cancer in women.

 

LiverCancer

Polesel, J, Talamini, R, et al. Nutrients Intake and the Risk of Hepatocellular Carcinoma in Italy. Eur J Cancer 43(16)2381-7.

A hospital-based case-control study was conducted in Italy in 1999-2002, including 185 patients with liver cancer and 412 cancer-free controls.  It looked at the effect of dietary consumption of linoleic acid and beta carotene on the risk of developing liver cancer. It found an inverse correlation between these variables, suggesting the consuption of foods rich in these nutrients protected against the disease.

 

Cancer of the mouth

Garewal, HS, Katz, RV, et al. Beta-Carotene Produces Sustained Remissions in Patients with Oral Leukoplakia: Results of a Multicenter Prospective Trial. Arch Otolaryngol Head Neck Surg 125(12)1305-10.

This study was done to confirm reports that beta-carotene produces regressions in patients with oral leukoplakia, a premalignant condition of the mouth.  Fifty four patients were studied for six months.  It was found that beta carotene helped to improve this condition, preventing it to develop in cancer.

 

Resveratrol's Health Benefits

Liu, Y, Ma, W, et al. Effect of Resveratrol on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials. Clin Nutr 34(1)27-34.

This study combined several studies and found that resveratrol consumption significantly decreases the blood pressure level at the higher dose, while resveratrol has no significant effects on DBP levels. Additional high-quality studies are needed to further evaluate the causal conclusions.

 

Mukherjee, S, Dudley, JI, et al. Dose-Dependency of Resveratrol in Providing Health Benefits. Dose Response 8(4)478-500. PMC2990065

 

This review study looked at the treatment with resveratrol at different dosages.  It was found that, at lower dose, resveratrol can be very useful in maintaining the human health, especially heart health whereas at higher dose, resveratrol has pro-apoptotic actions on healthy cells, but can kill tumor cells

 

Ghanim, H, Ling Sia, C, et al. An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol. J Clin Endocrinol Metab. 95(9)

This study was done on humans, testing the effect of resveratrol.  It was found to be both an anti-oxidant and anti-inflammatory.  Both of these effects are considered anti-aging effects

Anthocyanins and your Health

Kowalczyk, E, Fijalkowski, P, et al. The Influence of Anthocyanins from Aronia Melanocarpa on Selected Parameters of Oxidative Stress and Microelements Contents in Men with Hypercholesterolemia. Pol Merkur Lekarski 19(113)651-3.

This study showed that anthocyanins increase the detoxification ability of the liver and also assists with the elimination of toxic metals.  It also increased zinc in red blood cells which is a positive effect on health in general, and serve as an anti-oxidant.

 

Cassidy, A, Mukamal, K, et al. High Anthocyanin Intake Is Associated with a Reduced Risk of Myocardial Infarction in Young and Middle-Aged Women. Circulation 127(2)188-96.

This study was done in a group of young woman.  The reason being that there was not much research done in this group regarding the development of myocardial infarctions.  It was found that a high intake of Anthocyanins may reduce MI risk in young women.

Ellagic Acid and Health

Falsaperla, M, Morgia, G, et al. Support Ellagic Acid Therapy in Patients with Hormone Refractory Prostate Cancer (Hrpc) on Standard Chemotherapy Using Vinorelbine and Estramustine Phosphate. Eur Urol. 47(4)449-54.

This study was done on men with prostate cancer who received chemotherapy.  Some of the participants received ellagic acid with the treatment.  It was found that the intervention group receiving he ellagic acid, had less negative side effects while they had a better survival rate and objective response.  The study suggests that the use of ellagic acid as support therapy reduces chemotherapy induced toxicity, in particular neutropenia.

 

Mansouri, MT, Farbood, Y, et al. Beneficial Effects of Ellagic Acid against Animal Models of Scopolamine- and Diazepam-Induced Cognitive Impairments. Pharm Biol 54(10)1947-53.

 This study was done on animals, however, it suggests the potential of EA supplement in the treatment of dementia seen in elderly persons.  This could restore some of the memory loss under certain conditions

 

Mertens-Talcott, SU, Lee, JH, et al. Induction of Cell Death in Caco-2 Human Colon Carcinoma Cells by Ellagic Acid Rich Fractions from Muscadine Grapes (Vitis Rotundifolia). J Agric Food Chem 54(15)5336-43.

This study demonstrated the anticancer properties of ellagic acid rich extracts from red muscadine juice through the inhibition of multiplication of cancer cells, and the induction of apoptosis (cell death) in cancer cells.

Dark red fruit and vegetables

The study or studies below found some significant facts regarding health effects of certain food.  This is an attempt by us to interpret the findings so that it could be implemented in everyday health practices.  It has to be understood that good eating habits are necessary for optimal health and that means that a variety of good foods have to be consumed every day.  We do believe that some food has medicinal value and could be used to help in the prevention and support of treatment in certain illnesses.  However, if it is not part of a good nutritious diet, it might lose its value.    Although we do believe in the power of natural food, we absolutely do not claim to cure any disease through the consumption of specific food.

McAnulty, LS, Collier, SR, et al. Six Weeks Daily Ingestion of Whole Blueberry Powder Increases Natural Killer Cell Counts and Reduces Arterial Stiffness in Sedentary Males and Females. Nutr Res 34(7)577-84.

This study was done on sedentary men and woman.  It showed that six weeks of ingenstion of blueberries increases the mechanism where cancer cells are killed off in the body.  It also reduces arterial stiffness and consequently high blood pressure and the risk of stroke and cardiac disease.

 

Holcombe, R, Martinez, M, et al. Effects of a Grape-Supplemented Diet on Proliferation and Wnt Signaling in the Colonic Mucosa Are Greatest for Those over Age 50 and with High Arginine Consumption. Nutr J. 2015; 14: 62. 14(62)PMC4472174

 

This study showed that the consumption of grapes protects against colon cancer, and even more so in people over the age of 50 and at risk for the development of the disease

Biesinger, S, Michaels, H, et al. A Combination of Isolated Phytochemicals and Botanical Extracts Lowers Diastolic Blood Pressure in a Randomized Controlled Trial of Hypertensive Subjects. Eur J Clin Nutr. 2015 Jun 10. Epub 2015 Jun 10.

This was a randomized control trial.  The data support the theory that this combination of polyphenols (combination of extracts from grape seed and skin (330 mg), green tea (100 mg), resveratrol (60 mg)) reduced diastolic pressure by potentiating eNOS activation and nitric oxide production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.

Cruciferous Vegetables and Blood Vessels

The study or studies below found some significant facts regarding health effects of certain food.  This is an attempt by us to interpret the findings so that it could be implemented in everyday health practices.  It has to be understood that good eating habits are necessary for optimal health and that means that a variety of good foods have to be consumed every day.  We do believe that some food has medicinal value and could be used to help in the prevention and support of treatment in certain illnesses.  However, if it is not part of a good nutritious diet, it might lose its value.    Although we do believe in the power of natural food, we absolutely do not claim to cure any disease through the consumption of specific food.

X, M, Y, B, et al. Sulforaphane Prevention of Diabetes-Induced Aortic Damage Was Associated with the up-Regulation of Nrf2 and Its Down-Stream Antioxidants. Nutrition & Metabolism. . Nutr Metab 9(1)84. PMC3495894 [1]

These results suggest that diabetes-induced aortic fibrosis, inflammation, and oxidative damage can be prevented by the sulforaphane in cruciferous vegetables.

Cruciferous Vegetables and Pain

The studies below found some significant facts regarding health effects of certain food.  This is an attempt by us to interpret the findings so that it could be implemented in everyday health practices.  It has to be understood that good eating habits are necessary for optimal health and that means that a variety of good foods have to be consumed every day.  We do believe that some food has medicinal value and could be used to help in the prevention and support of treatment in certain illnesses.  However, if it is not part of a good nutritious diet, it might lose its value.    Although we do believe in the power of natural food, we absolutely do not claim to cure any disease through the consumption of specific food.

Baenas, N, Gonzalez-Trujano, ME, et al. Broccoli Sprouts in Analgesia - Preclinical in Vivo Studies. Food Funct 8(1)167-76.

This study proved that while broccoli sprout extract could serve as a pain killer, it had no side effects such as gastric damage or any sedative effects

Cancer and Cruciferous Vegetables

The studies below found some significant facts regarding health effects of certain food.  This is an attempt by us to interpret the findings so that it could be implemented in everyday health practices.  It has to be understood that good eating habits are necessary for optimal health and that means that a variety of good foods have to be consumed every day.  We do believe that some food has medicinal value and could be used to help in the prevention and support of treatment in certain illnesses.  However, if it is not part of a good nutritious diet, it might lose its value.    Although we do believe in the power of natural food, we absolutely do not claim to cure any disease through the consumption of specific food.

Zhang, Y, Talalay, P, et al. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc Natl Acad Sci U S A 89(6)2399-403. PMC48665

It is already known that the consumption of vegetables, especially cruciferous vegetables, reduces the risk of developing cancer. This paper identified that the consumption of cruciferous vegetables increases the production of 2nd phase liver detoxification enzymes, thus speeding up detoxification.  These findings underscore the role of toxins in the development of cancer and how detoxification could protect against development of the disease.  

 

Riso, P, Martini, D, et al. DNA Damage and Repair Activity after Broccoli Intake in Young Healthy Smokers. Mutagenesis 25(6)595-602.

In this study 27 young, healthy smokers consumed steamed broccoli to test the effect on DNA damage caused by smoking.  It was found that the DNA was protected from damage.  This was an indication that the overall antioxidant status of these smokers improved because of the diet high in sulforaphane.